Cutaneous lymphoma Cutaneous lymphoma is a tumor formed by the accumulation of malignant lymphocytes in the skin, mainly of two sources, T or B cells, but T cells account for the majority. Skin lesions may appear as patches, plaques, lumps, nodules, ulcers, etc. In progressive disease, lymph node enlargement and tumor cells may appear in peripheral blood, bone marrow or internal organs. In the early stage of the disease, it is difficult to distinguish dermatolymphoma from inflammatory skin diseases such as “dermatitis”, “eczema” and “psoriasis”. Therefore, skin pathology and genetic rearrangement should be performed for rashes that have failed to respond to treatment and have been recurring for several years. Early diagnosis of the disease is difficult and often requires multiple biopsies for a definitive diagnosis. The disease is a group of diseases with more than ten different types. According to the degree of malignancy, it is divided into inert developmental type and rapidly progressive type, and the survival period between these two types varies greatly. The malignancy of the disease can be estimated based on the immunophenotype of tumor cells and peripheral blood T cells. Systematic assessment of the presence of lymph node, blood, bone marrow and visceral invasion is also required to develop a treatment plan for the grading and staging of the disease. Most of the disease is of the inert type with a low level of malignancy, and only a few are of the rapidly progressive type with aggressive disease. None of the current chemotherapy regimens can stop the progression and recurrence of cutaneous lymphoma, but on the contrary, they lead to frequent recurrence of lesions with increased severity and systemic toxic side effects, shortening survival. In the early 1990s, the Department of Dermatology of Ruijin Hospital proposed a “non-chemotherapy approach” for the treatment of cutaneous lymphoma, which is slow to work, but effective in delaying recurrence and improving survival and quality of life. The treatment process of non-chemotherapy method is long, and persistent treatment can prolong the remission time and prolong the survival. Patients with cutaneous lymphoma should pay attention to the following in daily life and treatment: 1. Establish the concept of long-term coexistence with the disease, do not pursue the “cure”, avoid strain and stress anxiety. 2. 2. Skin care: keep the skin clean; use topical medication after UV phototherapy when combining topical medication and UV phototherapy; use skin barrier protector after bathing to prevent dryness; protect the skin in the radiotherapy irradiated area to prevent breakage. 3. Regularly self-observe the rash and touch the superficial lymph nodes. If there is an increase in rash, swollen lymph nodes, fever and other discomforts, consult a doctor promptly and, if necessary, perform biopsy on the skin or swollen lymph nodes, bone marrow, etc. 4, retinoic acid drugs (such as Avia) need to be taken for a long time or even for life, there will be discomfort such as dry lips, skin flaking, but also blood lipid changes, need to adjust the dose under the guidance of a doctor. 5, health care products and tonic products are not effective for the disease. 6, chemotherapy is still necessary for those who have extra-skin organ involvement and persistent fever. 7, regular follow-up, at least once every 3 months.