Continuous use of minoxidil hair appeared second wild hair loss, may be the normal role of the drug, may also be the adverse reaction of the drug, may also be the aggravation of the condition and so on. 1. The normal role of the drug: Minoxidil is a vasodilator, can promote hair epidermal vasodilatation, accelerate the local blood circulation, improve the microenvironment of hair growth, stimulate the hair growth of the hair loss site. After using the drug due to the improvement of hair growth microenvironment, it may cause resting hair to enter the regression phase earlier and lead to massive shedding. 2. Adverse reactions of the drug: If patients experience local irritation, such as localized rash with itching and tingling when using Minoxidil Apply, or if patients do not use the drug in strict accordance with the requirements, some adverse reactions may occur, leading to massive hair loss. 3. Exacerbation of the disease: during the use of medication, the patient did not combine with other drugs for treatment, purely external use of minoxidil, or if the patient is not timely removal of the causative factors of the disease, such as the continued use of irritating shampoos, or continue to stay up all night and so on, so that the condition is aggravated, may make a large number of hair loss. As there are more causes of massive hair loss due to continuous use of Minoxidil, patients are advised to go to the hospital for timely consultation and, at the same time, avoid stopping the drug or adjusting the dosage on their own, etc.