Tetralogy of Fallot surgery does not have a significant impact on life expectancy after surgery. This is because the technology for Tetralogy of Fallot surgery is now more sophisticated and because personal care after surgery also determines life expectancy. Tetralogy of Fallot is a congenital heart disease that occurs in pediatric patients with four structural malformations of the heart: ventricular septal defect, pulmonary stenosis, aortic ride, and hypertrophy of the right ventricle, and therefore requires surgery as soon as it is diagnosed. The main surgical methods are tetralogy of Fallot correction and palliative surgery. The surgical techniques have been gradually developed and matured through continuous research and operation, and the prognosis is good, with the vast majority of patients being able to live a normal life and play sports. Post-operative home care is the key point, three months after the operation should not be over-activity, to ensure adequate sleep, appropriate arrangements for the amount of activity, reduce the burden on the heart, enhance the heart’s ability to tolerate. Avoiding the patient’s emotional excitement, giving medication on time as prescribed by the doctor, keeping warm and preventing cold, and avoiding cross-infections, etc., generally will not affect the life expectancy. The vast majority of patients can thrive like normal children after active surgical treatment and long-term post-operative care.