The optimal heart rate range for patients with coronary artery disease should be slower than normal, especially when using beta-blockers such as metoprolol, the heart rate should be controlled at 55-60 beats per minute. Coronary heart disease is an ischemic heart disease in which atherosclerosis occurs in the coronary arteries, resulting in narrowing or occlusion of the lumen of the blood vessels, which leads to myocardial ischemia, hypoxia or necrosis. Normal people’s heart rate range of 60 ~ 100 beats / min, and coronary heart disease patients with a slightly faster heart rate, even if the heart rate is within the normal range, there may be an increase in myocardial oxygen consumption, myocardial ischemia aggravated, thus panic, chest tightness and other discomforts. Therefore, the optimal heart rate for patients with coronary heart disease should be slightly slower than normal, but not less than 50 beats/minute. When patients experience panic and other discomforts, beta-blockers such as metoprolol should be used as prescribed by the doctor to slow down the heart rate and reduce myocardial contractility, thereby reducing myocardial oxygen consumption and relieving symptoms. However, it should be noted that during the use of beta-blockers, it is advisable to control the target heart rate at rest (i.e., awake, inactive and quiet state) at 55~60 beats per minute, in order to effectively reduce the myocardial oxygen consumption, to meet the demand for cardiac blood supply, and to improve the patient’s prognosis. It should be noted that the heart rate of patients with coronary heart disease should be assessed by a professional doctor to determine the patient’s condition, and if necessary, follow the doctor’s instructions to use medication to avoid aggravating the condition. In addition, do not take medication on your own to avoid side effects such as bradycardia.