Severe bleeding after progesterone injection may be due to aggravation of preeclampsia, or the emergence of inevitable miscarriage, which needs to be treated by general treatment, medication (e.g., progesterone), surgical treatment and other ways. 1. Aggravation of preeclampsia: Pregnant women should take bed rest, avoid activities, prohibit sexual life, continue to use progesterone treatment as prescribed by the doctor, check blood Hcg and progesterone, and be diagnosed by a professional doctor according to the comprehensive diagnosis of the situation of pregnant women. 2. Inevitable abortion: the symptoms of preeclampsia can not be effectively controlled, bleeding and abdominal pain can not be alleviated, may be progressed to inevitable abortion, can be intravenous uterotonin, promote uterine contraction, is conducive to the discharge of products of pregnancy, or through the scraping operation to terminate the pregnancy. Bleeding aggravated after progesterone injection can be timely to the hospital, under the guidance of the physician to carry out the relevant treatment.