Glucocorticoid is a hormone secreted by the adrenal cortex and is regulated by the hypothalamic-pituitary-adrenal axis. Excessive glucocorticoid secretion is seen in the following conditions: i. Adrenal adenoma, adenocarcinoma or hyperplasia. When adenoma, adenocarcinoma or adrenal hyperplasia occurs in the adrenal glands, increased glucocorticoid secretion will occur. Hypothalamic and pituitary lesions. Adrenocorticotropin-releasing hormone secreted by the hypothalamus and adrenocorticotropic hormone secreted by the pituitary gland can act on the adrenal glands and promote increased glucocorticoid secretion by the adrenal glands. Third, ectopic ACTH syndrome. A few malignant tumors, such as lung cancer, can develop ectopic ACTH syndrome and increase secretion of adrenocorticotropic hormones, thus promoting excessive secretion of glucocorticoids by the adrenal cortex.