Low-grade intraepithelial neoplasia of the ascending colon is defined as the presence of conventional atypical hyperplasia, mild heterogeneous hyperplasia, and moderate heterogeneous hyperplasia in the mucosa of the ascending colon. The treatment of low-grade intraepithelial neoplasia of the ascending colon includes general treatment, surgical treatment and so on. 1. General treatment: In daily life, attention should be paid to adjusting the diet, avoiding spicy, greasy and stimulating food, etc. Meanwhile, regular follow-up should be carried out. At the same time, regular follow-up is needed. 2. Surgical treatment: It is suitable for patients with severe symptoms such as diarrhea and other needs. Under the condition of enteroscopy, we can perform lesion removal surgery, or lesion intestinal resection, etc. The specific surgical method should be based on the patient’s condition. The specific surgical method should be based on the patient’s condition. After the diagnosis of low-grade intraepithelial neoplasia of the ascending colon, it is necessary to choose the appropriate treatment plan according to one’s own condition and under the guidance of the doctor.