What is peritoneal infusion chemotherapy for malignant tumors?

Tumor recurrence and metastasis are the core problems of tumor treatment failure and affect survival. Among them, malignant ascites caused by tumor abdominal metastasis or peritoneal infiltration is a common clinical complication of malignant tumors, and the median survival is usually only a few weeks to a few months, with a 1-year survival rate of <10%. Common tumors causing this condition include: gastric cancer, colorectal cancer, pancreatic cancer, liver cancer, ovarian cancer, uterine cancer, lymphoma, etc. For such cases, in addition to symptomatic treatment and passive ascites drainage, warm intraperitoneal perfusion chemotherapy has shown some clinical effectiveness. This method kills metastatic tumor cells through three ways: 1. Higher temperature (43~45℃) acting on human tumor cells can lead to their apoptosis or necrosis; 2. Higher local concentration of chemotherapeutic drugs in the abdominal cavity can act directly on tumor cells; 3. High temperature has a sensitizing effect on chemotherapeutic drugs.