Callus, tinea pedis, metatarsal warts and other possible causes of thick and hard feet can be improved through medication, physical therapy, enhanced care and other methods. 1. callus: the feet are often subjected to friction, long-term pressure and other adverse factors, may stimulate the foot skin epidermal layer thickening, thus appearing foot skin thick and hard and other symptoms, pay attention to wear comfortable and soft shoes and socks, to avoid excessive friction of the feet. 2. tinea pedis: feet by a variety of fungal infections can lead to the occurrence of tinea pedis, which scaly keratosis pilaris can make the patient appear foot skin thick and hard, rough, cracked and so on, such patients can be applied locally naftifen ketoconazole, miconazole ointment and other medications to help improve the symptoms, the serious need to take itraconazole, terbinafine, and other medications to help the treatment. 3. metatarsal warts: human papilloma virus infection of the skin of the feet may lead to metatarsal warts, so that the patient appears foot skin thick and hard, rough and uneven, pain and other symptoms, such patients can be through the laser, freezing, electrocautery and other physical methods to help the treatment, but also the use of fluorouracil ointment, imiquimod ointment ointment ointment and other ointment localized application to help improve the symptoms. It should be noted that the above treatments should be carried out under the guidance of a physician, and the medication should be used in accordance with the doctor’s instructions to avoid the occurrence of adverse reactions.