Tonsillitis is more serious after infusion, it may be that the disease is in a progressive stage, or the treatment is not right, etc. Tonsillitis needs to be treated with appropriate antibiotics or antiviral drugs according to the type of infection. Bacterial tonsillitis is commonly streptococcal infection, but also Staphylococcus aureus, Clostridium difficile infection, preferred penicillin treatment, the initial treatment of 2-3 days after no improvement, it is recommended that according to the pharyngeal swab culture and sensitivity tests to choose cephalosporins, such as cefuroxime, cefdinir, cefixime, or macrolides such as azithromycin symptomatic treatment. If the treatment of tonsillitis in children is unsuccessful, we need to be alert to EBV and cytomegalovirus infection, and the tonsillar secretion is grayish-white in color, and at the same time, there will be high fever, rash, enlarged liver and spleen, and enlarged cervical lymph nodes, and so on, so we can choose the treatment of acyclovir and ganciclovir, and so on. Tonsillitis more serious after infusion needs timely follow-up, actively find the pathogen, according to the cause, change the appropriate treatment.