Treatment of pancreatic fistula usually takes about 3 months. The first step in the principle of pancreatic fistula treatment is to inhibit pancreatic secretion, including extracorporeal nutritional support, inhibition of pancreatic enzyme activity and the use of drugs such as growth inhibitors. The second step is to perform pancreatic fistula drainage, including drainage of various percutaneous tubes, drainage through surgery or transendoscopic drainage, and surgical resection of the sinus tract or sinus grafting if necessary. As pancreatic fistulae are mostly caused by chronic diseases, such as chronic pancreatitis, pancreatic cancer and other diseases, and the corrosive nature of the pancreatic fluid, it is usually more difficult to do surgery immediately after discovery, and a slower, but relatively safe treatment is needed to ensure that the patient can adapt and recover properly, a process that usually takes about 3 months.