Cephalosporin is better or clindamycin is better according to the specific treatment of the disease and the patient’s physical condition, there is no absolute good or bad. Clindamycin is a bacteriostatic agent for infections caused by staphylococcus spp. and anaerobic bacteria, for example, it is effective in the treatment of otitis media, purulent tonsillitis, and pustular chest. It is contraindicated in patients with enteritis, ulcerative colitis, and those who are allergic to this drug. Cephalosporin is a bactericide, and there are five generations of cephalosporin antibiotics. Cephalosporin I and II are better for infections caused by gram-positive bacteria, such as upper respiratory tract infections, and from Cephalosporin III, the activity is enhanced for infections caused by gram-negative bacteria, which can be used for urinary tract infections. Cephalosporin IV and Cephalosporin V are more effective. It should not be used in patients who are allergic to penicillin or cephalosporin, and should not be used after drinking alcohol. The use of cephalosporin and clindamycin is not absolutely good or bad, according to the disease and the patient’s physical condition to decide which one to choose, the use of antibiotics should be decided by the doctor, can not be self-determination.