Dry and itchy lips may be caused by physiological factors such as skin dehydration, or it may be caused by diseases such as perioral dermatitis and lipitis. 1. Physiological factors: daily drinking less water, may trigger dry skin, dehydration, part of the population will appear dry and itchy skin around the edge of the lips. 2. Perioral dermatitis: its cause is not clear, may be inappropriate cosmetics, ultraviolet light and other factors, the patient’s perioral, chin and other places will appear pimples, scales, itching and so on. 3. Lipitis: the formation of lipitis may be related to sun exposure, climate change and local irritation and other factors, the patient’s lips and the surrounding area may appear swollen, peeling, dry and itchy and so on. There are many reasons for dry and itchy lips, and after excluding physiological factors, it is recommended that patients seek medical examination to clarify the cause of the disease.