If there is no diarrhea and blood in stool and weight loss, liver cirrhosis with esophagogastric fundal variceal bleeding, colorectal cancer, hepatocellular carcinoma, gastric cancer and other diseases should be considered, and targeted treatment, such as medication and surgery, should be carried out under the guidance of doctors. 1. Cirrhosis with bleeding esophagogastric fundal varices: patients with cirrhosis may suffer from loss of appetite, followed by emaciation, and when complicated by rupture and bleeding of esophagogastric fundal varices, they will suffer from blood in stool and emaciation. At this time, posterior pituitary hormone can be given to stop bleeding, and triple-lumen and two-bladder tubes can be used to stop bleeding as well as surgical intervention to stop bleeding. 2. Colorectal cancer: there may be symptoms of emaciation and blood in stool; bevacizumab, cetuximab and other medicines can be used for treatment as prescribed by doctors, and radiotherapy and surgical resection can be carried out when necessary, and surgical methods mainly include open surgery and laparoscopic surgery. 3. Liver cancer: patients with liver cancer may have the symptoms of wasting, and due to the decrease of coagulation function, blood in stool may also occur; it is necessary to strengthen nutritional support, and combined with hepatitis B can be treated with entecavir, and immunotherapy and surgical treatments such as hepatectomy and liver transplantation can also be considered. 4. Gastric cancer: gastric cancer can cause blood in stool when it erodes blood vessels, and gastric cancer itself can also cause wasting; omeprazole can be used to inhibit gastric acid secretion, morphine can be used to relieve pain, and radical surgery or palliative surgery can be carried out, as well as pabrolizumab immunotherapy. Patients with diarrhea and blood in the stools are advised to go to the hospital for treatment under the guidance of a doctor.