Holiday heart syndrome” is a syndrome characterized by clinical arrhythmias after excessive alcohol consumption during the holidays. This syndrome is not related to a long history of heart disease, but is closely related to alcohol consumption. Excessive consumption of alcohol, whether wine, beer or spirits, can cause folding to occur due to the ability of alcohol and its metabolites to delay myocardial conduction time or stimulate the release of norepinephrine from the myocardium, thereby altering the myocardial nonresponse period. These factors can make excessive drinkers susceptible to tachyarrhythmias, premature beats, tachycardia, and even abnormal heart rhythms such as atrial flutter or atrial fibrillation. For everyone, to effectively avoid holiday syndrome, make a scientific activity schedule or work schedule before going on vacation is the first thing to do. During the holidays, you should consciously combine work and rest, work and rest on time, and never do whatever you want. School students should do a good job of psychological adjustment, to remind themselves that the new semester has begun, must enter the study state as soon as possible. Workers should remind themselves to enter the normal work state as soon as possible, do not let the “holiday excitement” to work. In fact, the “holiday syndrome” is mostly due to disorderly living, too much socializing or lack of self-discipline, and not good at self-regulation, leading to physical and mental exhaustion and emptiness, the formation of holidays after the tension, worry, boredom and other adverse symptoms. Therefore, to avoid and prevent “holiday syndrome”, the key is to have a moderate, calm and good state of mind, make plans or arrangements for holidays in advance, learn to make psychological and physiological adjustments, so that the biological clock is maintained to a state of relaxation. The first and foremost treatment principle is to abstain from alcohol to prevent the recurrence of the above-mentioned symptoms from further worsening and forming serious arrhythmias or causing heart failure. The second is to give intravenous fluids to promote the timely excretion of alcohol and reduce the damage to the heart. The third is to monitor the electrocardiogram of a few patients with malignant arrhythmias such as atrial flutter or atrial fibrillation, and to administer the necessary antiarrhythmic drugs. In general, after the above treatment, especially within 6-12 hours after the cessation of alcohol consumption, the arrhythmia signs disappear and the heartbeat rhythm and frequency return to normal, so the prognosis is good. In conclusion, the key to preventing “holiday heart syndrome” is to actively stop or reduce alcohol consumption, especially during the holidays to be able to control themselves, less alcohol is appropriate.