There is no clinical term for which connective tissue disease is the mildest, and aggressive treatment of connective tissue diseases is advocated. Connective tissue diseases are a group of autoimmune diseases with multi-system and multi-organ involvement, including systemic lupus erythematosus, rheumatoid arthritis, polymyositis/dermatomyositis, polyarteritis nodosa, and dry syndrome. There is usually no lightest term for the above diseases. The development of connective tissue diseases is related to a variety of factors such as heredity, own gene mutation, infection, medication, etc., and some patients have a tendency to heal on their own. Although there is no cure for connective tissue disease, patients can usually relieve their discomfort and improve their quality of life by actively cooperating with their doctors and taking relevant treatment measures. In the course of medication, if intolerable adverse reactions occur, timely follow-up is needed to adjust the treatment plan according to the condition. It is recommended that people diagnosed with connective tissue disease adjust their mindset and follow the doctor’s instructions. Pay attention to daily skin care, avoid strenuous exercise, quit smoking and drinking, etc. Pay attention to the diet should be light, eat less animal offal, fried, barbecue and other spicy and greasy food. Follow up with the rheumatologist regularly as prescribed by the doctor.