Blisters on the glans need to identify the cause, which may be caused by genital herpes, contact dermatitis, fixed drug rash, herpes zoster, etc. Targeted treatments, such as medication, physical therapy, and surgical treatments, will be carried out under the guidance of the doctor. 1. Genital herpes: a common sexually transmitted disease, mainly manifested as blisters, vesicles or ulcers around the genitals, which may be accompanied by itching, burning sensation and pain. Topical antiviral agents (e.g., acyclovir cream) may be used, and antiviral drugs (e.g., famciclovir, acyclovir) are primarily used. 2. Contact dermatitis: It is an inflammatory reaction at the contact or non-contact site caused by skin contact with certain external substances. It is often characterized by erythema, swelling, papules, blisters and even blisters. The principle of treatment is to find the cause of the disease, get rid of allergens and symptomatic treatment. 3. Fixed drug rash: often occurs in the oral cavity and genital skin mucosa junction. Clinical manifestations of limited round, or round-like border clear edematous bright red or purplish-red spots, serious blisters, blisters. Treatment should first stop the use of drugs, if necessary, under the guidance of a physician to use anti-allergy drugs or hormone drugs, symptomatic treatment. 4. Herpes zoster: it is an acute inflammatory skin disease caused by varicella zoster virus and can occur in any part of the body. The affected part of the first flushed spot, followed by the emergence of most of its clusters of clusters of corn grain to mung bean-sized papules, quickly turned into blisters. The blisters are often arranged along the dermal nerves in a band, and the skin is normal between each group of blisters. The principle of treatment is antiviral, anti-inflammatory and pain relief and prevention of secondary infection. However, it is not excluded that it is caused by other factors, it is recommended that the patient consult a doctor in time, the doctor to clarify the cause of the disease, give targeted treatment, do not blindly self-medication.