Ultra-high urine leukocyte and bacterial counts indicate the presence of urinary tract infections, possibly urethritis, cystitis, prostatitis and other diseases. 1. Urethritis: It is usually caused by gonorrhea or non-gonorrhea pathogens, and is also related to sexual contact transmission. Blood tests are often performed, and infected patients often show increased white blood cell counts, while gonococcal infections are accompanied by extremely high bacterial counts. 2. Cystitis: usually due to bacterial infection, but also related to drugs, radiation therapy, foreign objects and other factors. Generally, patients with bacterial cystitis can have a high urine white blood cell and bacterial count, but they also need to undergo urine culture and drug sensitivity tests to identify the type of infecting bacteria, so as to choose the appropriate antibiotic treatment. 3. Prostatitis: usually due to pathogen infection or other reasons, mostly related to irregular sex life, alcoholism, sedentary, spicy diet and other factors. And patients with bacterial prostatitis can show urine leukocytes and bacterial counts that are super high during urinalysis. It is recommended that patients with ultra-high urine leukocyte and bacterial counts should seek prompt medical attention to clarify the cause of the condition under doctor’s evaluation, and to treat the condition aggressively.