Progesterone is generally referred to as luteinizing hormone, which is mainly produced by the corpus luteum and is an important progesterone. The main physiological role of progesterone is to promote the thickening of the endometrium, causing the blood vessels and glands therein to proliferate and secrete mucus in preparation for the implantation of a fertilized egg, which is important for the maintenance of a normal menstrual cycle and a normal pregnancy. During pregnancy, progesterone originates primarily from the placenta and acts on the corpus luteum to regulate the synthesis of prostaglandins in that tissue. Increased progesterone may mean that a woman is pregnant and is also seen in conditions such as hyperemesis gravidarum, adrenal cancer, Cushing’s syndrome, multiple ovulations, multiple pregnancies, gestational hypertension syndrome, and essential hypertension. Decreased progesterone is often seen in disorders such as ovulation disorders, ovarian hypoplasia, anovulatory menstruation, amenorrhea, total hypopituitarism, preeclampsia, and luteal insufficiency. When abnormal progesterone occurs, it is recommended to consult a doctor for further examination and targeted treatment or therapy with the help of a doctor.