1, Family factors Family members or immediate family members with congenital genetic disorders, such as familial cerebral palsy, mental disorders, mental retardation, epilepsy, familial congenital malformations, habitual abortion, stillbirth, stillbirth, etc. 2, maternal factors (prenatal factors) delivery under 16 years old and over 40 years old, first birth over 35 years old, habitual abortion, multiple births, diabetes mellitus, giant baby, pre-eclampsia, viral infection (such as TORCH) in the first trimester, X-ray exposure, smoking, alcoholism, long-term medication, blood type incompatibility, expectant toxicity, mother with epilepsy, mental retardation, hyperthyroidism, etc. 3, delivery factors (intrapartum factors) long labor, placenta praevia, placenta abruptio, aging, early water breakage, amniotic fluid abnormalities, umbilical cord abnormalities, intrauterine distress, hyperemesis, twin births, multiple births, cesarean section, breech position, high mid position forceps assisted delivery, fetal head attraction, intracranial hemorrhage, severe asphyxia secondary to neonatal hypoxic ischemic encephalopathy, etc. 4.Neonatal factors Low weight infant, huge infant, premature infant, overdue infant, neonatal asphyxia, neonatal convulsion, severe jaundice, postpartum respiratory and circulatory disorders, birth injury, intracranial hemorrhage, infection (otitis media, pneumonia, sepsis, meningitis), hypoglycemia, severe anemia, feeding difficulties, etc.