Drugs that are not suitable for use in combination with ACEIs are mainly ARBs, which are angiotensin receptor antagonists. In the cardiovascular field, it is not recommended to combine these two drugs, which refer to sartans and prilosec, because their effects are very similar, and the adverse effects are more consistent. If the two drugs are combined, the adverse effects will be more likely to occur, but in nephrology some experts recommend the use of the two drugs together, because it can reduce proteinuria, reduce renal damage, but in the cardiovascular field is not recommended to carry out the joint use. For example, perindopril is not recommended for timosartan, irbesartan, valsartan, the combination of these drugs. In addition, ACEIs are not recommended for use in combination with newer drugs to prevent the progression of heart failure, such as Nosinotropic. Because of the same principle, their effects tend to have a superimposed effect, the adverse effects will also have a superimposed effect, so it is not recommended to use in combination.