When fever occurs after vaccination with the 13-valent vaccine, you should pay attention to analyzing the cause of the fever and give appropriate treatment to the cause of the fever. 1. Fever after vaccination with the 13-valent vaccine should first be considered as an adverse reaction caused by the vaccine. If the temperature is above 38.5℃, you can take ibuprofen and Xiao Chaihu granules to reduce fever. If the fever is low, it is recommended to drink more warm water, and physical hypothermia is the main cause. 2. Fever after 13-valent vaccination should be considered as an allergic reaction. Such patients may also have skin rash, itchy skin, and so on. These patients can take oral loratadine and cetirizine for anti-allergy treatment. 3. Consideration should also be given to the combination of infectious diseases, such as bacterial infections and other causes. You can further go to the fever clinic of the hospital, and test the blood routine for evaluation. Bacterial infections can be treated with amoxicillin and cefaclor. Fever after vaccination, it is recommended to go to the hospital, under the guidance of the doctor for relevant treatment. Medication should be administered under the guidance of a doctor and should not be abused.