Anyone who is not using contraception, has a normal sex life, and has not conceived after one year of cohabitation is called infertile. Among the factors of female infertility, the most common is tubal factor, followed by ovarian factor. Premature Ovarian Failure (POF) is a condition in which the ovaries do not ovulate due to a decline in ovarian function, thus causing infertility. Not all patients with premature ovarian failure can’t conceive naturally, some patients with premature ovarian failure do not have a complete loss of ovarian function, the ovaries will have intermittent ovulation phenomenon, this part of the patients with premature ovarian failure can conceive naturally. For patients who cannot conceive naturally for a long period of time, they need to consult the Department of Reproductive Medicine, and under the guidance of specialized doctors, they will be dealt with according to different situations. If the patient’s ovaries have intermittent functional recovery, and when dominant follicles are observed, follicle-monitoring-guided coitus, artificial insemination or natural cycles and IVF are applied to try to conceive, and sometimes medication is used to promote ovulation or rely on egg donation to help the patient resolve her fertility requirements. For low fertility or infertility caused by premature ovarian failure, the choice of treatment should vary from person to person, and the treatment method should be based on the advice of a professional doctor, and should not blindly use hormone drugs.