Reduced platelets first need to identify the cause of the disease, according to the cause of the treatment, usually taking glucocorticoid drugs, transplantation, stimulation of bone marrow hematopoietic drugs, splenectomy to restore normal platelets. Thrombocytosis may be caused by true erythrocytosis, primary thrombocythemia, primary myelofibrosis in early stage and chronic myeloid leukemia, acute infections, acute hemolysis, cancer and so on. The more common acute hemolysis is recommended to take glucocorticoid drugs, such as prednisone, dexamethasone and other medications, chronic myeloid leukemia can be treated with targeted drugs, hematopoietic stem cell transplantation surgery, and acute infections can be treated with anti-infective therapy. Thrombocytopenia may be caused by aplastic anemia, leukemia, viral infections, immune disorders, and so on. Aplastic anemia can be treated by avoiding triggering factors and taking drugs such as stanozolol to stimulate bone marrow hematopoiesis; leukemia requires chemotherapy and targeted drug therapy; thrombocytopenia caused by immune causes requires the use of glucocorticoids; and if necessary, it can be treated by splenectomy and thrombopoietic drugs. Because the causes of platelet abnormality are many, and the abnormalities have their own characteristics, so the method of restoring the normal level is also different, it is best to identify the causes and then give targeted treatment and therapy.