The typical clinical manifestations of nephrotic syndrome are: massive proteinuria, hypoproteinemia, edema, and hyperlipidemia. Most of these patients come to the clinic because of edema in low hanging areas such as the face and lower extremities. The diagnosis of nephrotic syndrome is easy, but the choice of treatment plan is very mysterious. First, a kidney puncture is required to identify the type of pathology. Among them, membranous nephropathy is the most common, and the treatment requires the application of hormones and immunosuppressants, and the common regimen is prednisone combined with tacrolimus. The microscopic lesion type is mostly seen in children and adolescents, treatment with hormones alone is possible, and the efficacy is usually very good. In case of recurrent attacks, cyclophosphamide can be added to the treatment. Although nephrotic syndrome cannot be cured, it can be treated with drugs to achieve clinical cure, prevent recurrence and improve quality of life.