What is the best time to take antihypertensive medication, in the morning or in the evening? Whether to take them before or after a meal is a frequent question from patients with high blood pressure. If it is a long-acting drug, it can be taken once a day. Generally, if it is taken once a day, it should be taken half an hour after waking up in the morning, not before or after meals, although some drugs are not disturbed by food, but if there is no stomach disease, it is recommended to take it more than 20 minutes before eating. If the medication is taken twice a day, the first dose should be taken within half an hour after waking up in the morning, and the second can be taken between 4 and 6 pm. If 24-hour blood pressure monitoring is available, the medication can be taken 1-2 hours before the peak as guided by the results of the 24-hour blood pressure monitoring. If 24-hour ambulatory blood pressure monitoring is not available, patients can choose 4 points in the day and take their blood pressure every 6 hours for 3 days to be able to know their blood pressure fluctuations. From this, you can also deduce a time to take the medication yourself. Secondly, the characteristics of blood pressure fluctuations, blood pressure fluctuations are usually high during the day and low at night spoon curve, blood pressure during the day there are two peak stages, one is 6:00 am to 10:00 am, one is 4:00 pm to 6:00 pm, this part of the patient if you take long-acting drugs, take one time in the morning can be. However, there are a few patients who have a curve where the difference between day and night disappears, or even an inverse spoon-shaped curve of high at night and low during the day. In addition to taking one antihypertensive drug in the morning, these patients should take an additional antihypertensive drug in the evening to cover the increase in blood pressure at night and avoid target organ damage. Finally, it depends on the action characteristics of the drugs, for example, diuretics should be taken once in the morning to avoid taking them at night, which will cause an increase in the number of nighttime urination and affect sleep.