The chemotherapy regimen for intrahepatic cholangiocarcinoma varies according to the severity of patients’ conditions, which may include gemcitabine + cisplatin + albumin paclitaxel, 5-fluorouracil + oxaliplatin, gemcitabine + oxaliplatin, and so on. 1. Gemcitabine + Cisplatin + Albumin Paclitaxel: This regimen is suitable for patients with stable condition and good physical condition due to the use of triple drug chemotherapy. 2. 5-fluorouracil + oxaliplatin: this regimen is a double combination of drugs, which is the second line of clinical chemotherapy, and the advantage of using this regimen is that it can make the patients have a longer survival cycle and protect the liver function of the patients at the same time. 3. Gemcitabine + oxaliplatin: this program is conducive to downgrading the clinical stage of patients with localized metastases and subsequent surgical treatment. Patients found with intrahepatic cholangiocarcinoma should go to the hospital for consultation in time and choose appropriate chemotherapy regimen according to the characteristics of intrahepatic cholangiocarcinoma, etc. The specific regimen should be formulated by doctors.