Antihypertensive drugs do not have the least side effects, basically every antihypertensive drug has side effects, you should choose your own suitable antihypertensive drugs according to your own situation. The most common antihypertensive drugs are the following five categories. 1. Calcium antagonists: such as nifedipine and felodipine. These drugs may cause lower limb edema, headache, gingival hyperplasia and other side effects. 2. Diuretics: such as hydrochlorothiazide, furosemide and so on. These drugs may cause side effects such as disturbance of water-electrolyte balance and hypokalemia. 3. Beta-blockers: e.g. metoprolol, sotalol, bisoprolol, etc. These drugs may cause side effects such as bronchial asthma and sinus bradycardia. 4. Angiotensin-converting enzyme inhibitors: such as Benadryl hydrochloride, Enalapril, Captopril and so on. These drugs may cause cough, hyperkalemia, gastrointestinal reactions and other side effects. 5. Angiotensin II receptor antagonists: such as valsartan, irbesartan, chlorosartan and so on. These drugs may cause dizziness, panic, insomnia and other side effects. Every antihypertensive drug has certain side effects, to effectively reduce side effects, you should choose the right antihypertensive drug for you according to your own situation. The use of medication should be under the guidance of a doctor.