Dry and itchy skin is associated with physiologic and pathologic factors. Antihistamine, glucocorticoid, hypoglycemic drugs can be given according to the etiology. 1. Age factor: age factor, skin dehydration, excessive cleaning, dry climate, leading to dry and itchy skin. It is recommended to pay attention to skin care, use moisturizing cream, reduce the frequency of bathing, avoid hot water scalding, etc. can relieve dry and itchy skin. 2. Pathological factors: (1) Skin allergy: contact with allergens, eating food that easily induces allergy, leading to dry and itchy skin. Antihistamines such as diphenhydramine and loratadine can be given, which can help relieve the symptoms. (2) Dry eczema: lack of sebum and excessive water loss cause dry eczema, resulting in dry and itchy skin. Medications such as hydrocortisone butyrate and mometasone furoate cream can be given to help relieve the symptoms. Oral antihistamines can be given when necessary. (3) Diabetes mellitus: long-term high blood sugar patients, resulting in skin microcirculation, peripheral nerve damage, resulting in dry and itchy skin. It is recommended that under the guidance of a doctor to give Apo sugar tablets, metformin, insulin, etc. to control blood sugar, can help relieve the symptoms. The causes of itchy skin are more, it is recommended that patients do not blindly use drugs, you need to go to the hospital for examination first, to clarify the cause, for the cause of the treatment.