Sore throats in children do not always require antibiotics; antibiotics can only be considered for illnesses where a bacterial infection is clearly present, and commonly used clinical medications include cefixime. There are many causes of sore throat in children, including acute infection of the upper respiratory tract caused by viral, bacterial, and atypical pathogen infections, and mucosal damage to the throat caused by crying and eating hard objects. Only pharyngitis and tonsillitis caused by bacteria and atypical pathogens need to be treated with antibiotics. For bacterial and atypical pathogen infections, it is usually necessary to judge the medication regimen based on the results of bacterial culture and drug sensitivity tests, etc. Experienced physicians can carry out empirical medication at the early stage of the disease. For bacterial infections, drugs such as penicillin and cefuroxime can be chosen; for mycoplasma and other pathogens, antibiotics such as azithromycin can be chosen; for viral infections, usually symptomatic treatment, such as sore throat and fever, acetaminophen and other antipyretic and analgesic drugs can be used. For mechanical injury to the mucous membrane of the throat, usually no medication is needed, and attention should be paid to keeping the oral cavity clean and hygienic. The above drugs need to be used under the guidance of clinicians; the occurrence of sore throat, it is recommended to consult a doctor promptly.