Walking ankle joint pain is the cause of clinical trauma caused by ankle joint instability, osteoarthritis, gouty arthritis, rheumatoid arthritis, talar necrosis and other causes. 1. Ankle instability caused by trauma: previous trauma history leads to local ligament injury without timely and regular treatment, long-term ankle instability. 2. Osteoarthritis: mostly occurs in elderly patients and patients with previous trauma to the ankle joint, X-ray film shows localized bone cumbersome formation and osteosclerosis. 3. Gouty arthritis: pain occurs when eating a high-purine diet, accompanied by local redness and elevated skin temperature, etc. Most patients have significantly elevated blood uric acid. 4. Rheumatoid arthritis: generally accompanied by symmetrical pain and discomfort in multiple joints of both hands, and most of the patients are positive for rheumatoid factor in hematological examination. 5. Talus necrosis: traumatic fracture of the talus or other causes, early cystic changes in the talus localization, late cartilage peeling, talus collapse. The cause of walking ankle joint pain is more complex, but also need to consider physiological reasons such as excessive weight bearing and strenuous exercise in the ankle area, resulting in local lactic acid accumulation, etc. If there is no improvement after resting, it is recommended to go to the hospital in time.