Endocrine disorders caused by closed mouth acne should be adjusted from life, drug treatment, acne removal surgery treatment. 1. Life regulation: usually to reasonable diet, eat more fresh fruits and vegetables, eat less spicy stimulation, high sugar, high calorie food, such as cream cake, chili, wine, animal fat, fried food. To go to bed early and get up early, to ensure adequate sleep, moderate outdoor exercise, to avoid too much mental stress. Normally, sunscreen, reduce ultraviolet radiation. 2. Drug treatment: the first choice of drugs is vitamin A acid drugs, more commonly used is tazarotene, adapalene, etc., combined with inflammation can choose peroxybenzoyl and azelaic acid. If you are a woman, you can take spironolactone, blood estradiol cyproterone and other drugs to regulate hormones. 3. acne removal: in the topical application of drugs at the same time can choose the acne squeezer to squeeze out the acne, this operation should be carried out in sterile conditions to avoid infection. The same disease patients with different physical conditions, the severity of the disease is different, the method of treatment is also different, should follow the doctor’s instructions for the correct treatment.