Patients with premature ovarian failure may clinically present with amenorrhea, infertility, and low estrogen symptoms, which can be examined through physical examination, ultrasonography, and blood hormone testing. Premature ovarian failure refers to the phenomenon that women experience amenorrhea and other sexual dysfunction before the age of 40 due to the failure of ovarian function. Common tests are as follows: 1. Physical examination: patients with premature ovarian failure may have vulvar atrophy, vaginal atrophy and other manifestations. 2. Vaginal ultrasound: patients with premature ovarian failure may have a small uterus and obvious atrophy of both ovaries. 3. Blood hormone examination: patients with premature ovarian failure may have significantly elevated follicle stimulating hormone FSH. When women before the age of 40 have symptoms of low estrogen such as hot flashes and excessive sweating, low libido, or amenorrhea, infertility, etc., they should consult a doctor in time for diagnosis and treatment.