In general, the pulse pressure difference reaches 80~100mmHg there will be some danger, the normal pulse pressure range should be between 30~40mmHg. Pulse pressure difference of 80~100mmHg is an increase in pulse pressure difference, and the body manifests excessive pulse pressure when the difference between systolic and diastolic pressure is large, and the possible reason for this is that the formation of atherosclerotic plaques leads to a decrease in the elasticity of the blood vessel wall. Increased pulse pressure difference may lead to damage to target organs such as heart, brain and kidney, such as heart failure, cerebrovascular aneurysm formation, renal failure, etc., and these damages may cause life-threatening situations when they develop to the end stage. Therefore, patients with a pulse pressure difference of 80~100mmHg should be actively treated and the primary disease should be searched for, so as not to cause life-threatening damage to the target organs.