There is no correlation between elevated alkaline phosphatase values and liver cancer. Elevated alkaline phosphatase can be seen in hepatobiliary and bone metabolism related diseases, and the sensitive and relatively specific diagnosis of liver cancer is alpha-fetoprotein. Alkaline phosphatase is mainly derived from the liver and bones. Alkaline phosphatase is mainly derived from the liver and bone. It is elevated to varying degrees in hepatobiliary diseases such as acute hepatitis, cirrhosis, cholelithiasis, and hepatocellular carcinoma, but there is no strict correlation between the elevated value and the specific disease. In addition alkaline phosphatase is a marker of active osteogenic activity and can be elevated in hyperthyroidism, fibrous osteitis, fracture healing, and osteogenic bone tumors. The best marker for the diagnosis of hepatocellular carcinoma is alpha-fetoprotein, and alpha-fetoprotein > 400 ng/ml can be one of the bases for the diagnosis of hepatocellular carcinoma based on the exclusion of other diseases. In the presence of imaging evidence and the presence of alpha-fetoprotein >200ng/ml for 8 weeks, the possibility of hepatocellular carcinoma should also be highly suspected. It is recommended that patients with elevated alkaline phosphatase should go to the hospital as soon as possible to identify the cause of the elevation and to provide targeted treatment.