It is possible for bone metastases to hurt more and more each day. This phenomenon may be due to the primary cancer lesion not being effectively controlled or serious osteoporosis caused by bone metastasis. After some patients have received active anti-cancer treatment, the primary tumor lesions are still not effectively controlled. The tumor still presses blood vessels, lymph, nerves and other tissues, so the pain relief effect of bone metastasis is relatively poor, and most of the patients will continue to have pain with aggravation. Bone metastases may lead to osteoporosis, which causes changes in muscle tone around the bone tissue, thus triggering persistent pain. Patients with bone metastases should be treated under the guidance of a specialist and reviewed regularly to avoid further progression of the disease.