1. Abdominal pain. About half of the patients have right upper abdominal pain and distension or discomfort, weight loss, loss of appetite and other symptoms, which are often regarded as early warning symptoms of cholangiocarcinoma. At the beginning of abdominal pain, there are similar to cholelithiasis and cholecystitis. According to clinical observation, abdominal pain and jaundice can appear only 3 months after the onset of cholangiocarcinoma. Jaundice. Most patients consult doctor for jaundice, which is the earliest and the most important symptom of cholangiocarcinoma, about 90%-98% of cholangiocarcinoma patients have different degrees of yellowing of skin and sclera. Jaundice is characterized by progressive aggravation and deepening, and it is mostly painless, while jaundice is fluctuating in a few patients. Jaundice of upper bile duct cancer appears earlier, and jaundice of middle and lower bile duct cancer can appear later because of buffering of gallbladder. Itching of skin. It may appear before or after the appearance of jaundice, and it may also be accompanied by other symptoms such as tachycardia, bleeding tendency, mental depression, fatigue, fatty diarrhea, abdominal distension, etc. Itching of skin is caused by the increase of bilirubin content in the blood, which stimulates the skin peripheral nerves. 4, appear such as nausea, vomiting. Even emaciation, dark yellow urine, such as soy sauce or strong tea, light yellow stool or even clay color, etc. When the tumor is ulcerated in the late stage, there may be biliary hemorrhage, black stool, positive fecal occult blood test, and even anemia; when there is liver metastasis, there may be liver enlargement, cirrhosis and other signs. 5. Hepatomegaly and cirrhosis. Bile duct cancer in late stage is prone to distant spread and metastasis, when liver metastasis occurs, liver enlargement, cirrhosis and portal hypertension may appear.