Adrenal cancer in advanced stage will show the following symptoms. 1. Malignant disease manifestation: patients will have symptoms of generalized decline such as emaciation, fatigue, loss of appetite, mental deterioration and so on. 2. Endocrine disorders: due to abnormal secretion of adrenal hormone, adrenal cancer will show symptoms such as high blood pressure, electrolyte disorders, full moon face and obesity. 3. Tumor compression: adrenal cancer mass enlarges and compresses abdominal viscera, resulting in obvious swelling and pain. 4. Tumor metastasis: adrenal cancer in late stage is often accompanied by distant metastasis, such as liver metastasis, which will cause abdominal pain and jaundice; lung metastasis, which will cause hemoptysis and even respiratory difficulties; brain metastasis, which will cause cerebral edema, headache and vomiting; bone metastasis, which will cause bone pain and even pathological fracture, and so on. To summarize, adrenal cancer in late stage will have various manifestations. It is recommended that patients cooperate with doctors to reduce pain and prolong survival.