The cost of lumbar puncture of cerebrospinal fluid mainly includes: lumbar puncture 180 yuan, local infiltration anesthesia 40 yuan, extra large change of medication 40 yuan, cerebrospinal fluid manometry 40 yuan, cerebrospinal fluid routine examination 6 yuan, cerebrospinal fluid biochemical examination 16 yuan, cerebrospinal fluid general bacterial culture plus drug sensitivity 111 yuan, cerebrospinal fluid general smear examination 7 yuan, all of the above are the cost of each operation and examination, each hospital charges slightly different. The indications for this test are: 1. diseases requiring knowledge of changes in cerebrospinal fluid pressure and composition. 2. diseases requiring contrast injection and air, etc. for imaging to observe the condition of the spinal subarachnoid space, cerebral subarachnoid space and ventricular system. 3. diseases requiring cerebrospinal fluid replacement and intrathecal drug injection for treatment.