With the trend of hypertension becoming younger, the incidence of erectile dysfunction due to hypertension will further increase. In the daily outpatient clinic, it is not uncommon to see patients who come to the clinic with erectile dysfunction and are diagnosed with hypertensive disease. Erectile dysfunction can occur as a direct consequence of hypertension or as an adverse reaction to antihypertensive medications. Erectile dysfunction induced by antihypertensive medications will have a direct impact on the patient’s ability to adhere to their medication and has a bearing on their quality of life. Of course, not all antihypertensive drugs have the risk of inducing erectile dysfunction, and different types of antihypertensive drugs have different effects on erectile function. At present, the commonly used antihypertensive drugs have the following categories: 1, diuretics. Diuretics are one of the most important and widely used anti-hypertensive drugs, and several studies have shown that diuretics are the most influential antihypertensive drugs on erectile function. Overseas studies have shown that small doses of thiazide diuretics increase the incidence of erectile dysfunction in hypertensive patients by two times. Diuretics on the erectile function of the mechanism of the following aspects: (1) diuretics can reduce the effective circulating blood volume, systemic tissue blood supply is reduced, affecting the penile cavernous blood supply, resulting in erectile dysfunction; (2) hydrochlorothiazide, tachycardia, etc. can cause hyperglycemia or hypokalemia caused by the adverse effects of systemic fatigue, resulting in penile erection is not firm; (3) diuretics cause electrolyte disorders in the use of the process, especially in the serum zinc Ion concentration decreases, zinc ions are closely related to the erectile process, thus causing erectile dysfunction; (4) potassium-preserving diuretics spironolactone has an anti-androgenic effect, which can accelerate the rate of conversion of serum testosterone to estradiol in the body, but also has obvious luteinizing hormone activity, luteinizing hormone is a libido suppressant, and long-term use of spironolactone increases the clearance of the androgenic hormone testosterone in the liver, so that testosterone in the blood concentration decrease, affecting penile erection. Therefore, diuretics should be used with caution in patients with hypertension accompanied by erectile dysfunction. 2. β-blockers. Blocking the β2 receptor can cause a decrease in perfusion pressure or penile cavernous smooth muscle diastolic insufficiency leading to erectile dysfunction. This class of drugs is generally named so-and-so lorazepam. It is recommended to choose the third generation of highly selective β1-adrenergic receptor antagonists to reduce the risk of erectile dysfunction. 3. Calcium channel antagonists. There are various drugs in this class, named so-and-so diphenhydramine, and almost all of them have an effect on erectile dysfunction. The main reason is that their mechanism of action is related to calcium channels in the mechanism of penile erection, and it is recommended to choose carefully. 4, angiotensin converting enzyme inhibitors and angiotensin II receptor antagonists. The former is named so-and-so Pril, and the latter has valsartan and chlorosartan. These two types of drugs do not have a significant effect on sexual function, the latter has been reported in the literature on sexual function and promote the effect, we have also been confirmed in the clinical use.