Mastocytosis is the most common breast disease in women. Among the patients with breast diseases seen in general hospitals, more than 80% of them are seen for breast pain and lumps, most of which are clinically diagnosed as mastocytosis. The diagnosis of mastocytosis is mainly as follows: 1. Clinically, there are single or multiple lumps in one or both breasts, and the examination of the breast can be palpated with single or multiple irregular nodules of different sizes, tough, mostly located in the outer upper part, the nodules are not adherent to the surrounding tissues and can be pushed, often with mild tenderness, and the axillary lymph nodes are not large. 2.Most of them are accompanied by cyclic breast pain, and most of them have obvious relationship with emotion and menstrual cycle. Generally, the symptoms are aggravated about a week before menstruation, and the pain of the lump is obviously reduced after menstruation, and cannot be relieved by itself for 3 consecutive months, excluding physiological breast pain. 3.Use ultrasound, mammogram and nuclear magnetic examination to exclude malignant lesions. 4. If necessary, perform needle aspiration cytology and local biopsy to exclude breast cancer, breast fibroids and other benign and malignant diseases.