Mastocytosis is the most common breast disease, with the highest incidence of breast diseases and a prevalence of 60% to 80% among young and middle-aged women. Because it has a 2% incidence of breast cancer, it must be given some attention. However, because of its high incidence, there is controversy among specialists as to whether all mastocytosis needs to be treated. Currently, some treatment is recommended for more serious cases of breast enlargement, such as premenstrual or menstrual periods, where breast swelling and pain significantly affect daily life. For those with no obvious symptoms, follow-up and screening according to the NCCN screening guidelines are still advocated. The development of mastocytosis is mainly caused by endocrine hormone imbalance. It is generally believed to be caused by an imbalance in the ratio of progesterone (P) to estrogen (E) secretion and an imbalance in the P/E2 ratio (PEL). Breast enlargement disease belongs to the category of “breast fetish” in Chinese medicine, which was described in the Ming Dynasty’s “The Authentic Book of Surgery” as: “Breast fetish is a nodule in the breast, in the form of pills and eggs, or heavy and painful, or not painful, the skin color does not change, the nucleus can vary with happiness and anger, mostly from thinking about the injury to the spleen, anger and liver, depressed and become. ” At present, the view that dysregulation of the flushing and liver qi stagnation jointly cause the disease is basically widely accepted. At present, there is no ideal treatment plan for mastocytosis in Western medicine. Endocrine therapy is still the main measure, and there is a lack of specific drugs. Western medicine treatment is preferred to the estrogen receptor antagonist triamcinolone acetonide, which can achieve good clinical efficacy, but may interfere with the balance of human hormones, prone to relapse after stopping the drug, long-term use, the risk of inducing endometrial cancer, and can also cause liver function damage. It is not easy to be accepted by patients and should not be used as regular medication. In addition, progesterone, methyltestosterone, danazol and other hormonal drugs have large side effects and should not be taken for a long time. Although vitamin drugs, iodine preparations and diuretics have some efficacy on this disease, they cannot be the first choice of treatment. Chinese herbal medicine currently accounts for a large proportion of the treatment of mastocytosis. According to the viewpoint of dialectical treatment in TCM, at present, treatment is based on draining the liver and regulating the qi and regulating the flushing, and the medicine used corresponds to the main formula of Prosperity San and Erxian Tang with appropriate addition and subtraction. Clinical results have been quite good. Some physicians also advocate the use of blood circulation and elimination of blood stasis, which has also achieved more satisfactory results. In general, Chinese medicine treatment should still pay attention to dialectical treatment and adopt individual treatment plans according to the patient’s individual condition. To summarize the current Chinese and Western medical protocols for the treatment of mastocytosis, for mastocytosis with severe symptoms, Western medical endocrine therapy can control the symptoms faster and has better efficacy for short-term use, but it should not be used for a long time. To avoid recurrence after use, Chinese medicine treatment can be combined. For patients with relatively mild symptoms, the use of TCM treatment can be considered, which can avoid the side effects of western medicine and play an effective role in treating both the symptoms and the root cause. Combining Chinese and Western medicine is the best choice for most mastopathy that requires clinical treatment. Finally, we would like to remind women that regular follow-up is the most important thing, especially for women with high risk factors for breast cancer, and regular follow-up is an effective means for early detection, diagnosis and treatment of breast cancer.