The time of awakening of comatose patients depends on the cause of the coma, and the time of awakening may be different if the etiology is different. In internal medicine patients with cerebral infarction, for example, which leads to coma, the coma time is determined by various factors such as the size of the cerebral infarction, the site of the infarction, the midline shift situation, the brain herniation situation, and the underlying disease and complications. Most patients in coma due to cerebral infarction can be awake within two weeks, or may be awake within a week. Coma due to brain infarction is mainly seen in large brain infarction or brain stem infarction. In the case of large brain stem infarction, it is very dangerous and can lead to coma, cerebral edema, and in severe cases, it can be dangerous such as brain herniation, which requires surgery. If a patient with cerebral infarction is in a coma, it indicates a critical condition, and it may be more difficult to wake up again if the coma is not awake within three weeks due to cerebral infarction.