Many Parkinson’s patients experience unexplained pain in different parts of the body. When doing actions such as zipping, unbuttoning, or emptying pockets in daily life, the movements are often more difficult because of the pain, which is not so severe that pain medication is necessary, but is very distressing. The pain can be neck and shoulder pain, headache, back pain, and most often, soreness in the arms or legs. It is now believed that the main reason for the pain is because of localized muscle stiffness. Most patients have pain that can be relieved with the relief of muscle stiffness after treatment with medications such as levodopa, but later in the course of the medication, spasmodic pain in the toes occurs instead, due to the adverse effects of levodopa.