Cold hands and feet during fever is a physiological phenomenon due to the regulation of the thermoregulatory center, which increases heat production and decreases heat dissipation. When a person suffers from infections or rheumatic diseases that can cause fever, the thermoregulatory center of the hypothalamus plays a regulatory role by raising the body temperature set point and enhancing the function of the monocyte-macrophage system, thus helping the body to resist pathogens. Raising the body temperature set point not only increases the body’s heat production, but also reduces the body’s heat dissipation, resulting in fever and cold hands and feet. On the one hand, the skeletal muscle tremors that occur during fever increase the body’s heat production. On the other hand, the blood vessels on the surface of the body contract, the blood flow decreases, the body heat dissipation decreases, resulting in the emergence of cold hands and feet. If you have a fever, you should go to the hospital in time for standardized treatment and use drugs under the guidance of the doctor to avoid delaying your condition.