Most diabetic patients with insufficient basal insulin secretion cannot be reversed. Pancreatic function may be reversed in obese type 2 diabetic patients with intensive treatment. 1. Obesity-related type 2 diabetes mellitus: pancreatic islet function may be reversed in obesity-related type 2 diabetes mellitus patients after intensive lifestyle intervention, metabolic surgery, or hypoglycemic agents may be induced. 2. Type 1 diabetes mellitus: patients with type 1 diabetes mellitus have absolute insulin insufficiency and require hormone replacement therapy with exogenous insulin, and the islet function of patients with type 1 diabetes mellitus is generally not reversible. Patients with insufficient basal insulin secretion should be medicated under the guidance of a physician according to their condition.