Statins (representative drugs include atorvastatin, resevastatin, simvastatin, etc.) are one of the most important drugs for the prevention and treatment of cardiovascular and cerebrovascular diseases. The elderly mostly suffer from cardiovascular and cerebrovascular diseases and need to take them at this time. When taking them, the following issues should be noted: 1. Elderly people need to consider the use of statins due to the declining function of liver and kidneys, the presence of other diseases and the combination of various medications. The benefits and risks of statin therapy need to be taken into account when using them, weighing the pros and cons. For example, digoxin, amiodarone and clarithromycin, which are commonly used in elderly patients with cardiovascular disease, can increase the concentration of statins in the blood and increase the risk of adverse reactions, so the drug should be replaced, the dose should be reduced and monitoring should be strengthened if necessary. 2, drinking large amounts of grapefruit juice can inhibit the metabolism of statins in the small intestine, increase their bioavailability and blood concentration, increasing the risk of myopathy and rhabdomyolysis, which should be avoided as much as possible. 3. Elderly people with hypothyroidism should also pay attention to the use of statins, as they are less tolerable to statins. 4. Elderly patients have less cholesterol elevation than adults due to the reduced ability of their liver to synthesize cholesterol and the possible coexistence of chronic wasting diseases. 5.There are many kinds of statins, so it is necessary to individualize them and start with small doses, and pay attention to monitoring liver and kidney function and creatine kinase. If muscle pain and muscle weakness occur, prompt medical consultation is required and serum creatine kinase level should be reviewed in time to exclude statin-induced myositis, myalgia or rhabdomyolysis. 6. During statin therapy, LDL-C values should be monitored, with different target ranges depending on the condition, and the dosage should be adjusted under the guidance of a specialist.