First of all, let’s understand what is meant by interventional treatment. As we know, surgical treatment is done after surgical exposure; medical treatment is done by taking medication; but interventional treatment is not like an exposed, open surgery that is completely open, and it is not a surgery that is treated by medication, it is between the two, so American doctors named it intervention (meaning interventional intervention), and it is called interventionalist treatment. “Interventional treatment” is the same as “surgery without surgery”. In simple terms, interventional treatment is the least invasive treatment method that involves making tiny channels of a few millimeters in diameter in blood vessels or skin, or through the body’s original channels, and treating the lesion locally under the guidance of imaging equipment (angiography, fluoroscopy, CT, MR, B ultrasound) without opening the lesion. It is characterized by low trauma, simplicity, safety, effectiveness, few complications and significantly shorter hospital stay. The purpose of analgesia is to reduce pain and improve quality of life by using the least invasive and most effective treatment for the patient, and neurointerventional techniques can do this and have played an important role in the treatment of PHN and many other neurogenic pains. Neurointerventional treatment also involves blocking the nerves innervating the lesion through a minimally invasive channel with targeted localization of the imaging equipment. The traditional method of blockade is pharmacological blockade, including glucocorticoid anti-inflammatory drugs, neurotrophic drugs, etc. Nowadays, trioxane intervention is proposed in the interventional treatment for postherpetic neuralgia (PHN). Among them, trioxane is, as the name implies, three oxygen atoms, namely ozone. Ozone is a strong oxidant, and blocking the nerve root through interventional therapy stimulates the overexpression of oxidative enzymes, neutralizes the overproduction of reactive oxidative products in the inflammatory response, antagonizes the release of immune factors in the inflammatory response, dilates blood vessels, improves venous return, and reduces swelling and adhesions of the nerve root, while acting as an anti-inflammatory and analgesic agent. Trioxane can also stimulate the release of enkephalins from inhibitory interneurons, which is an endogenous analgesic substance. In addition, this treatment can play an immunomodulatory role and improve and reduce the damage caused by tissue hypoxia. According to the clinical observation of experts, ozone fumigation plus triple oxygen nerve block is effective in treating PHN. 81.3% of patients were cured after 4 times of treatment, which is worthy of clinical application. II. Electrophysiological treatment of PHN Acupuncture therapy has always been recognized by the Chinese people and exists as part of traditional Chinese medicine, an ancient and esoteric medical system about the flow of energy (qi) along the channels (meridians) of the whole body, which was once pointed out to lack an objective basis, but currently, the mechanism of action of acupuncture therapy is being increasingly understood from a Western scientific point of view. We know that acupuncture therapy is mainly about “getting qi”, and that traditional acupuncture therapy is used to “get qi” from painful points or disease-related points by means of techniques such as lifting and twisting, so that the patient gets a sore and swollen feeling at the point of acupuncture, and the needle is left in the skin for 10 to 30 minutes. Adhering to the treatment, the qi vascular smoothly that is to achieve the therapeutic effect. The modern Western medical view that one of the mechanisms of acupuncture is to produce a weak electrical stimulation of the body to promote human recovery, this view can be traced back to ancient Rome, physicians use electric eels to treat human headaches and arthritis. This idea can be traced back to the ancient Roman times when physicians used electric eels to treat headaches and arthritis. Electrotherapy is the continuous, gentle stimulation of nerves, muscles and cells by an electric current of appropriate intensity and frequency, which stimulates the body to naturally produce pain-blocking and pain-relieving messages. Since acupuncture needles tend to slip off, break, and cause infection at the acupuncture site, experts have found that using electrodes instead of acupuncture needles on the relevant pain points and acupuncture points can also play a good therapeutic role, which is what we call Transcutaneous Electrical Nerve Stimulator (TENS), TENS). TENS has been clinically observed to be effective in blocking the afferent of injurious nociceptive information in the periphery, excite inhibitory interneurons in the center, and cause the release of central analgesic substances. In addition, the effects of TENS are no longer limited to pain relief alone; scientists have found that small amounts of sustained microcurrent stimulate self-regulation of damaged cells, re-establish blood and oxygen supply, and stimulate tissue regeneration by promoting local metabolic activity. This has played an important role in the treatment of shingles and PHN. Our famous academician, Prof. Han Jisheng, invented a Korean (HAN’S) analgesic instrument by studying the correlation of the analgesic mechanism of acupuncture and integrating the two modes of trans-needle (EA) and trans-dermal (TENS). This instrument activates endogenous analgesic substances in the body when stimulating the relevant area, prompting the release of endogenous opioid peptides to replace the function of exogenous morphine and exert systemic analgesic effects, and has the function of improving microcirculation, relieving muscle spasm, and exerting immunomodulatory effects. The electrophysiological therapy described above fully develops the traditional therapy of acupuncture analgesia in China, combines cell biology and macroscopic central pain inhibitory system, which can find some basis in modern science and convince people, and has remarkable efficacy, economy, simplicity, little side effects, and is easily accepted and recognized by patients.