Patients often ask questions such as “Why do I have Parkinson’s disease? What is the cause of Parkinson’s disease” and other similar questions, and even a lot of patients did physical examination, heard that the brain problem, went to take a brain MRI, the results show normal, some also blood, ultrasound and so on a bunch of. So what causes Parkinson’s disease and can it be detected by instruments? Parkinson’s disease is caused by a lesion in the substantia nigra region of the midbrain, resulting in a reduction in the amount of dopamine neurotransmitter production, which is unable to meet the normal bodily requirements, and a series of movement disorder symptoms. So far, there is still no instrument that can directly detect primary Parkinson’s disease. Clinical diagnosis is made by experts after questioning, according to the patient’s age, symptom manifestation and development, combined with anti-Parkinson’s disease medication, and the diagnostic accuracy is about 90%. Some patients will also do some tests, such as brain MRI, is also meaningful, as the need for differential diagnosis. So is it true that Parkinson’s disease can’t be found out? No. After continuous research, it is found that the causes of Parkinson’s disease may be related to the following factors. 1, age aging: generally older people are prone to Parkinson’s syndrome. After middle age, individuals susceptible to environmental toxins, after exposure to toxins, due to its detoxification dysfunction, subclinical nigrostriatal damage, aggravated with age, dopaminergic neurons progressive and constantly death and degeneration, and ultimately the loss of compensation to appear the clinical symptoms of Parkinson’s disease. 2.Environmental factors: There are some substances in the external environment, or chemicals similar to MPTP, such as pesticides, which may lead to the occurrence of Parkinson’s disease. 3.Family heredity: Parkinson’s disease seems to have a tendency of family aggregation, and the incidence rate of relatives of families with Parkinson’s disease patients is higher than that of the normal population. 4, genetic susceptibility: although the occurrence of Parkinson’s disease and aging and environmental toxins, but not all the elderly or exposed to the same environment, or even the same large number of MPTP inhalation of people will appear Parkinson’s disease. After a long period of follow-up research, the medical profession has found that no single factor can fully explain the cause of Parkinson’s disease, and most researchers tend to believe that the cause of Parkinson’s disease is the result of a combination of the above factors.