During the nucleic acid testing process, there is a certain risk of infection for the tester, the subject, and the specimen examiner, but the probability of infection is very low after proper sterilization and protection. First, because there is a standardized disinfection process, the sample collection tools and the tester’s own utensils are disposable, and healthcare workers will immediately disinfect the testing utensils and the surrounding environment after the collection of a subject’s samples, so the probability of cross-infection during the test is very low. Secondly, it is because of the cooperation of strict personal prevention and control. Considering that in addition to the nucleic acid sampling process, there is also the problem of high population density in the queue at the time of testing, test subjects are usually required to wear masks and keep a safe distance from the crowd. In addition, the probability of cross-infection is also reduced by leaving the testing site immediately after completion of the test, without overstaying, and disinfecting the area immediately after returning home. China is currently in an epidemic period of C. neoformans, and nucleic acid testing is the most important way to confirm the diagnosis of C. neoformans infection. Without proper disinfection and protection, even if you are not a patient with C.N.C., you may be infected with C.N.C., but after proper protection, the probability of infection by nucleic acid testing will be significantly reduced, and it is relatively safe and necessary. Tip: In this article, the terms “neocoronavirus pneumonia and novel coronavirus pneumonia” were renamed to “novel coronavirus infection” on December 26, 2022, as announced by the National Health Commission.